Dietary Supplements. Synbiotics (Probiotics, Prebiotics) for Men and Women Health
BENEFITS OF TAKING MEGAEL-DENA AS A SOURCE OF PROBIOTICS AND FRUCTOOLIGOSACCHARIDES
It is generally believed that taking supplements containing beneficial bacteria, compounds that stimulate their growth, or both (like MegaEl-Dena), is beneficial for health, especially for people with disturbances in the composition of endogenous microflora. It should be noted that clinical guidelines for the use of probiotics differ in different countries: in the US, they are considered as dietary supplements and thus cannot be formally considered to cure or treat any diseases (even if this is supported by clinical trials), whereas in European countries such claims are allowed and have to be substantiated by properly conducted human trials in the targeted population or in healthy volunteers [1]...
BENEFITS OF TAKING MEGAEL-DENA AS AN IMMUNOMODULATOR
Beneficial microorganisms, predominantly bacteria, which inhabit the gastrointestinal tract (collectively called commensal microbiota, or commensal microflora), protect our bodies from invasion by pathogenic microorganisms, either by direct competition with pathogens or via immunomodulation [1,2]. The latter mechanism may be particularly important because approximately 70% of immune system cells are located in the gastrointestinal tract [3]. Beneficial bacteria are also thought to enhance the epithelial barrier, which separates the content of the gastrointestinal tract with a multitude of microorganisms from the cells of the immune system located underneath the intestinal epithelium [4]...
BENEFITS OF TAKING MEGAEL-DENA FOR PATIENTS WITH GASTRIC AND DUODENAL ULCERS ASSOCIATED WITH HELICOBACTER PYLORI INFECTION
Many bacteria inhabiting the gastrointestinal tract are beneficial [1]; their important function is to protect the host from invasion by pathogenic microorganisms, either by direct competition or via immunomodulation [2,3]. However, some of these bacteria may be harmful. Helicobacter pylori is a Gram-negative bacterium of the Proteobacteria phylum that predominantly colonizes the stomach and induces inflammation. Overall, H. pylori is considered a harmful bacterium because its presence is a major risk factor for such diseases as gastric ulcer, duodenal ulcer, some cancers, and some cardiovascular and autoimmune diseases although at least some H. pylori strains protect from gastroesophageal reflux disease and esophageal adenocarcinoma and may also indirectly protect from asthma [4,5]. H. pylori infection often occurs in early childhood from infected mothers [6]...
BENEFITS OF TAKING MEGAEL-DENA FOR PATIENTS WITH ATOPIC ALLERGY
Many of the microorganisms that inhabit the gastrointestinal tract (commensal microbiota, or commensal microflora) can be considered as our symbionts; their important function is to protect our bodies from invasion by pathogenic microorganisms, either by direct competition or via immunomodulation [1, 2]. The latter mechanism may be particularly important because approximately 70% of immune system cells are located in the gastrointestinal tract [3]...
BENEFITS OF TAKING MEGAEL-DENA FOR PATIENTS WITH DIARRHEA
Diarrhea may be caused by a variety of factors; two major groups of conditions accompanied by diarrhea are due to various infections of the gastrointestinal tract and disturbances of the intestinal microbiota as a result of antibiotic therapy. Regardless of the exact cause of diarrhea, supplementation with probiotics, defined as “microorganisms that have a favorable influence on the host by improving the indigenous microflora” [1], may have beneficial effects in prevention or reducing the severity of diarrhea. In some cases, beneficial effects of prebiotics (food ingredients that are non-digestible for humans but stimulate the growth of beneficial bacteria (2)) have also been described. Fructooligosaccharides (FOS) are the most widely known prebiotics [2]. MegaEl-Dena contains both prebiotics (FOS) and probiotics, i.e. 8 species of viable beneficial bacteria, including 4 species of Bifidobacterium (B. bifidum, B. breve, B. lactis, and B. longum), 3 species of Lactobacillus (L. acidophilus, L. casei, and L. rhamnosus), and Streptococcus thermophilus. Below we consider in more detail, examples of studies that have documented the benefits of probiotics and prebiotics in patients with diarrhea...
BENEFITS OF TAKING MEGAEL-DENA FOR PATIENTS WITH DYSBIOSIS
The human body is inhabited by a variety of microorganisms, mainly bacteria, most of which reside in the gastrointestinal tract; these microorganisms are referred to as the commensal microbiota (or commensal microflora). It has been estimated that the number of bacterial cells in the human body exceeds the number of our own cells by one order of magnitude [1]. Because of the complex interactions among different bacterial species and between the host and the intestinal microbiota, our digestive tract can be considered as an ecosystem [2]. Many of these microorganisms can be considered as our symbionts; their important function is to protect the host from invasion by pathogenic microorganisms, either by direct competition or via immunomodulation [3, 4]...
BENEFITS OF MEGAEL-DENA FOR PATIENTS WITH BACTERIAL VAGINOSIS AND DURING PREGNANCY AND BREASTFEEDING
The human body is inhabited by at least 10,000 species of microorganisms (commensal microbiota, or microflora), many of which still remain to be identified [1]. They protect the host from invasion by pathogenic microorganisms, either by direct competition or via immunomodulation, and disturbances in the composition of the commensal microbiota (dysbiosis, or dysbacteriosis) are associated with a number of pathological conditions [2, 3]. Although most commensal microorganisms inhabit the gastrointestinal tract, some live in or on other parts of the body, such as the skin, buccal cavity, respiratory tract, and vagina, where they also benefit human health [4]...
BENEFITS OF TAKING MEGAEL-DENA FOR PATIENTS UNDERGOING ANTIBIOTIC THERAPY, CHEMOTHERAPY, AND RADIOTHERAPY
Some types of therapy, especially antibiotic therapy as well as chemotherapy and radiotherapy in cancer patients, can directly or indirectly damage the intestinal microbiota. Although antibiotics are intended to kill pathogenic bacteria, they reduce the total number of bacteria and cause changes in microbiota composition (dysbiosis); these changes are transient in most cases but may occasionally last for several months [1]. In particular, in babies and infants, antibiotic therapy has been reported to cause dramatic shifts in both the total numbers and composition of intestinal microbiota [2]. Antibiotic treatment can reduce bacterial abundance in babies’ feces (used as a proxy for the abundance of intestinal microbiota) by as much as six orders of magnitude, but the dynamics of the microbial species composition differs in different babies [2]...
REVIEW OF CLINICAL GUIDELINES FOR MEGAEL-DENA COMPONENTS
The volume of research on probiotics has steadily increased over the first 15 years of this century and probiotics are increasingly available to consumers, mostly as food supplements...